KMID : 1143420200130453221
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Public Health Weekly Report 2020 Volume.13 No. 45 p.3221 ~ p.3229
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Development of Laboratory Analysis System for unknown infectious diseases
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Jang Jun-Hyeong
Kim Il-Hwan Kim Eun-Jin Kang Byung-Hak Rhie Gi-Eun
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Abstract
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It is generally accepted that the rise of infectious diseases, both known and unknown, is linked to climate change and the
increase in international air travel. In response to the growing prevalence of unknown infectious disease outbreaks, the Korea Disease Control and Prevention Agency (KDCA) established guideline for Unknown Disease Outbreaks (2019), and operated the Laboratory Analysis Task Force (LATF) of Unknown Disease Outbreak (UDO) for identification and analysis of causative pathogens. The LATF categorized infectious diseases into five syndromes (respiratory, hemorrhagic, diarrheal, neurologic, and rash) and developed laboratory diagnosis algorithms and multi-pathogen panels for differential diagnosis of each syndrome. In addition, laboratory response tabletop exercises (TTX) were conducted to prepare for the occurrence of unknown respiratory disease outbreaks. Through this diagnostic system and TTX, the KDCA was able to aggressively respond to coronavirus-19 (COVID-19) from the initial stage of COVID-19 inflow into South Korea as a form of unknown pneumonia. In conclusion, this study recommended that the KDCA continue preparations for the improvement and supplement of diagnostic assay systems for the occurrence of unknown infectious diseases.
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KEYWORD
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Unknown diseases outbreak, Respiratory syndrome, Laboratory diagnosis algorithm, Multi-pathogen panel, Tabletop exercise
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